The Intenso project is about identifying the bottlenecks of the currently used downstream processing methods, and finding new solutions to circumvent them. This is highly relevant for any and all biotechnical products, as downstream processes account for more than 80% of the manufacturing costs. The Intenso approach will not concentrate solely on the effectiveness of the new methods, but will strive to lead to a sustainable approach, factoring in risk management derived from economic, environmental, and social developments, also including government policies and legal constraints.