Book:

• Proteases: Structure and Function, Klaudia Brix & Walter Stöcker (Eds.), Springer-Verlag Wien 2013. http://www.springer.com/de/book/9783709108840#aboutBook, ISBN 978-3-7091-0884-0, ISBN 978-3-7091-0885-7 (eBook)., doi:10.1007/978-3-7091-0885-7. , Springer Wien, Heidelberg, New York, Dordrecht, London. Library of Congress Control Number: 2013956226.

Selection (Original Articles / Reviews):

• Al-Hashimi, A., V. Venugopalan, M. Rehders, N. Sereesongsaeng, Z. Hein, S. Springer, E. Weber, D. Führer, M.S. Bogyo, C.J. Scott, R.E. Burden, and K. Brix (2020b) Procathepsin V is proteolytically active and secreted in a TSH regulated manner from human thyroid epithelial cells. Int. J. Mol. Sci., in press
• Al-Hashimi, A., V. Venugopalan, N. Sereesongsaeng, S. Tedelind, A.M. Pinzaru, Z. Hein, S. Springer, E. Weber, D. Führer, C.J. Scott, R.E. Burden, and K. Brix (2020a) Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells. BBA – Molecular Cell Research 1867, 118846. ShareLink: https://authors.elsevier.com/a/1blp8c5IDcJ7S. https://doi.org/10.1016/j.bbamcr.2020.118846
• Ziros, P.G., C.O. Renaud, D.V. Chartoumpekis, M. Bongiovanni, I.G. Habeos, X.-H. Liao, S. Refetoff, P.A. Kopp, K. Brix, and G.P. Sykiotis (2020) Mice hypomorphic for Keap1, a negative regulator of the Nrf2 antioxidant response, show age-dependent diffuse goiter with elevated thyrotropin levels. Thyroid. DOI: 10.1089/thy.2020.0044
• Falkowski, K., E. Bielecka, I.B. Thøgersen, O. Bochenska, K. Płaza, M. Kalinska, L. Sasiadek, M. Magoch, A. Pecak, M. Wisniewska, N. Gruba, M. Wysocka, A. Wojtysiak, M. Brzezinska-Bodal, K. Sychowska, A. Pejkovska, M. Rehders, G. Butler, C.M. Overall, K. Brix, G. Dubin, A. Lesner, A. Kozik, J.J. Enghild, J. Potempa, and T. Kantyka (2020) Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs) — A CleavEx Based Analysis. Int. J. Mol. Sci. 21(12), 4383. https://doi.org/10.3390/ijms21124383
• Dauth, S., H. Rakov, R.F. Sirbulescu, I. Ilies, J. Weber, B. Batbajar Dugershaw, D. Braun, M. Rehders, E.K. Wirth, D. Führer, U. Schweizer, and K. Brix (2020) Function of cathepsin K in the central nervous system of male mice is independent of its role in the thyroid gland. Cell. Mol. Neurobiol. 40, 695-710. https://doi.org/10.1007/s10571-019-00765-6
• Brix, K., J. Szumska, J. Weber, M. Qatato, V. Venugopalan, A. Al-Hashimi, and M. Rehders (2020) Auto-regulation of the thyroid gland beyond classical pathways. Exp. Clin. Endocrinol. Diabetes 128(6-07), 437-445. doi: 10.1055/a-1080-2969
• Biebermann, H. / K. Brix / D. Führer (2020) Seven Years of Active Thyroid Hormone Research in Germany: Thyroid Hormone Action beyond Classical Concepts. Exp. Clin. Endocrinol. Diabetes 128(6-07), 355-357. doi: 10.1055/a-1163-7355
• Szumska, J., Z. Batool, A. Al-Hashimi / V. Venugopalan / V. Skripnik, N. Schaschke, M. Bogyo, and K. Brix (2019) Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum. Biochimie 166, 270-285. https://doi.org/10.1016/j.biochi.2019.07.010
• Gruba, N. / E. Bielecka, M. Wysocka, A. Wojtysiak, M. Brzezińska-Bodal, K. Sychowska, M. Kalińska, M. Magoch, A. Pęcak, K. Falkowski, M. Wiśniewska, L. Sąsiadek, K. Płaza, E. Kroll, A. Pejkovska, M. Rehders, K. Brix, G. Dubin, T. Kantyka, and J. Potempa / A. Lesner (2019) Development of chemical tools to monitor human kallikrein 13 (KLK13) activity. Int. J. Mol. Sci. 20(7). pii: E1557. doi: 10.3390/ijms20071557
• Brix, K., M. Qatato, J. Szumska, V. Venugopalan, M. Rehders (2019). Thyroglobulin storage, processing and degradation for thyroid hormone liberation. In: The Thyroid and Its Diseases, edited by Markus Luster, Leonidas Duntas, and Leonard Wartofsky. Springer International Publishing AG, part of Springer Nature. https://doi.org/10.1007/978-3-319-72102-6_3
• Engels, K. / H. Rakov, G.S. Hönes, K. Brix, J. Köhrle, D. Zwanziger, L.C. Moeller, and D. Führer (2019) Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs. J. Gerontol. A Biol. Sci. Med. Sci. pii: glz040. doi: 10.1093/gerona/glz040
• Kuhnert, N., I.H. Said, A. Shrestha, A. Rezk, A. Grimbs, J. Nolzen, H. Schepker, K. Brix, D. Albach, and M. Ullrich (2018). Section: Medicinal Chemistry, Chapter 10: Rhododendron Natural Products as Sources of Novel Antibiotics. In: Rhododendrons International, pp. 142-151.
• Brix, K. (2018). Host cell proteases: cathepsins. In: Activation of Viruses by Host Proteases, edited by Eva Böttcher-Friebertshäuser, Wolfgang Garten, and Hans Dieter Klenk. Springer-Verlag. https://link.springer.com/chapter/10.1007/978-3-319-75474-1_10
• Qatato, M. / J. Szumska, V. Skripnik, E. Rijntjes, J. Köhrle, and K. Brix (2018). Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression. Front. Pharmacol. 9:221. doi: 10.3389/fphar.2018.00221
• Fischer, J., G. Kleinau, C. Rutz, D. Zwanziger, N. Khajavi, A. Müller, M. Rehders, K. Brix, C.L. Worth, D. Führer, H. Krude, B. Wiesner, R. Schülein / H. Biebermann (2017). Evidence of G-protein coupled receptor and substrate transporter heteromerization at a single molecule level. Cell. Mol. Life Sci. doi.org/10.1007/s00018-017-2728-1
• Oettmeier, C., K. Brix, and H.-G. Döbereiner (2017). Topical Review: Physarum polycephalum – a new take on a classic model system. J. Phys. D: Appl. Phys. 50, no. 41. https://doi.org/10.1088/1361-6463/aa8699
• Rakov, H., K. Engels, G.S. Hönes, K. Brix, J. Köhrle, L.C. Moeller, D. Zwanziger, D. Führer (2017). Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice. Biology of Sex Differences 8, 38. DOI 10.1186/s13293-017-0159-1.
• Badziong, J., S. Ting, S. Synoracki, V. Tiedje, K. Brix, G. Brabant, L.C. Moeller, K.W. Schmid, D. Führer, D. Zwanziger (2017). Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism. Eur. J. Endocrinol. 177, 243-250. Doi:10.1530/EJE-17-0279
• Said, I.H., A. Rezk, I. Hussain, A. Grimbs, A. Shrestha, H. Schepker, K. Brix, M.S. Ullrich, and N. Kuhnert (2017). Metabolome comparison of bioactive and inactive Rhododendron extracts and identification of an antibacterial cannabinoid(s) from Rhododendron collettianum. Phytochem. Anal. 28, 454–464. Doi:10.1002/pca.2694
• Grimbs, A., A. Shrestha, A.S.D. Rezk, S. Grimbs, I. Hakeem Said, H. Schepker, M.-T. Hütt, D.C. Albach, K. Brix, N. Kuhnert, and M.S. Ullrich (2017). Bioactivity in Rhododendron: A systemic analysis of antimicrobial and cytotoxic activities and their phylogenetic and phytochemical origins. Frontiers in Plant Science, 8, Article 551. Doi: 10.3389/fpls.2017.00551
• Couture, F., A.M. Jansen, P. Taghert, and K. Brix (2017). EJCB – Molecular basis of protein fates in the secretory and endocytic pathways, and beyond. Eur. J. Cell Biol. 96, 369–371. Doi:10.1016/j.ejcb.2017.06.006
• Weber, J., J. McInnes, C. Kizilirmak, M. Rehders, M. Qatato, E.K. Wirth, U. Schweizer, F. Verrey, H. Heuer, and K. Brix (2017). Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. Eur. J. Cell Biol. 96, 440-456. doi: 10.1016/j.ejcb.2017.02.002
• Tamhane, T., R. Illukkumbura, S. Lu, G.M. Maelandsmo, M.H. Haugen, and K. Brix (2016). Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells. Biochimie 122, 208-218
• Rezk, A., A. Al-Hashimi, W. John, H. Schepker, M.S. Ullrich, and K. Brix (2015b). Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells. BMC Complement Altern Med. 15:364
• Szumska, J., M. Qatato, M. Rehders, D. Führer, H. Biebermann, D.K. Grandy, J. Köhrle, and K. Brix (2015). Trace amine-associated receptor 1 localization at the apical plasma membrane domain of Fisher rat thyroid epithelial cells is confined to cilia. Eur. Thyroid J. 4 (Suppl. 1), 30-41
• Führer, D. / K. Brix / H. Biebermann (2015). Understanding the healthy thyroid state in 2015. Eur. Thyroid J. 4 (Suppl. 1), 1-8
• Brix, K., J. McInnes, A. Al-Hashimi, M. Rehders, T. Tamhane, M.H. Haugen (2015). Proteolysis mediated by cysteine cathepsins and legumain - recent advances and cell biological challenges. Protoplasma 252, 755-774
• Rezk, A., J. Nolzen, H. Schepker, D.C. Albach, K. Brix, and M.S. Ullrich (2015a). Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron. BMC Complementary & Alternative Medicine 15:67
• Haugen, M.H., K. Boye, J.M. Nesland, S.J. Pettersen, E.V. Egeland, T. Tamhane, K. Brix, G.M. Maelandsmo, and K. Flatmark (2015).  High expression of the cysteine proteinase legumain in colorectal cancer - Implications for therapeutic targeting. Eur. J. Cancer 51, 9-17
• Tamhane, T. / M. Arampatzidou, V. Gerganova, M. Tacke, R. Illukkumbura, S. Dauth, N. Schaschke, C. Peters, T. Reinheckel, and K. Brix (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol. Chem. 395, 1201-1219
• Führer, D. / K. Brix / H. Biebermann (2014). Übersicht / Review article: Schilddrüsenhormonwirkung – jenseits klassischer Konzepte. Das Schwerpunktprogramm „THYROID TRANS ACT“ (SPP1629) der Deutschen Forschungsgemeinschaft. Thyroid hormone action beyond classical concepts. The priority programme „THYROID TRANS ACT“ (SPP1629) of the German Research Foundation. Dtsch. Med. Wochenschr. 139, 492-496
• Haugen, M.H., H.T. Johansen, S.J. Pettersen, R. Solberg, K. Brix, K. Flatmark, and G.M. Maelandsmo (2013). Nuclear legumain activity in colorectal cancer. PLoS One 8(1), e52980
• Brix, K., D. Führer, and H. Biebermann (2011). Molecules imprtant for thyroid hormone synthesis and action - known facts and future perspectives. Thyroid Research 4 (Suppl 1), S9
• Dauth, S., R.F. Sirbulescu, S. Jordans, M. Rehders, L. Avena, J. Oswald, A. Lerchl, P. Saftig, and K. Brix (2011). Cathepsin K deficiency in mice induces structural and metabolic changes in the cenetral nervous system that are associated with learning and memory deficits. BMC Neuroscience 12, 74. 
• Dauth, S., M. Arampatzidou, M. Rehders, D. M. T. Yu, D. Führer, and K. Brix (2011). Thyroid cathepsin K - roles in physiology and thyroid disease. Clin. Rev. Bone Miner. Metab. 9, 94-106.
• Jordans, S., S. Jenko-Kokalj, N. M. Kühl, S. Tedelind, W. Sendt, D. Brömme, D. Turk, and K. Brix (2009). Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochemstry 10, 23. Highly Accessed.
• Mayer, K., A. Vreemann, H. Qu, and K. Brix (2009). Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Biol. Chem. 390, 471-480.
• Brix, K., A. Dunkhorst, K. Mayer, and S. Jordans (2008). Cysteine cathepsins: Cellular roadmap to different functions. Biochimie 90, 194-207
• Büth, H., P.L. Buttigieg, R. Ostafe, M. Rehders, S.R. Dannenmann, N. Schaschke, H.-J. Stark, P. Boukamp, and K. Brix (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. Eur. J. Cell Biol. 86, 747-761
• Brix, K., and S. Jordans (2005). News & Views: Watching proteases in action. Nature Chem. Biol. 1, 186-187.
• Brix, K. (2005). Chapter 05: Lysosomal Proteases: Revival of the Sleeping Beauty. In: Lysosomes, edited by Paul Saftig, Eurekah.com. Landes Bioscience. REVIEW.
• Friedrichs, B., C. Tepel, Th. Reinheckel, J. Deussing, K. von Figura, V. Herzog, Ch. Peters, P. Saftig, and K. Brix (2003). Thyroid functions of mouse cathepsins B, K, and L. J. Clin. Invest. 111, 1733-1745.
• Linke, M., V. Herzog, and K. Brix (2002). Trafficking of lysosomal cathepsin B – green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J. Cell Sci. 115, 4877-4889.
• Brix, K., M. Linke, C. Tepel, and V. Herzog (2001). Cysteine proteinases mediate extracellular prohormone processing in the thyroid. Review. Biol. Chem. 382, 717-725.
• Tepel, C., D. Brömme, V. Herzog, and K. Brix (2000). Cathepsin K in thyroid epithelial cells: Sequence, localization, and possible function in extracellular proteolysis of thyroglobulin. J. Cell Sci. 113, 4487-4498.
• Brix, K., P. Lemansky, and V. Herzog (1996). Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. Endocrinology 137, 1963-1974.
• Brix, K., and V. Herzog (1994). Extrathyroidal release of thyroid hormones from thyroglobulin by J774 mouse macrophages. J. Clin. Invest. 93, 1388-1396.
• Stockem, W., and K. Brix (1994). Analysis of microfilament organization and contractile activities in Physarum. Int. Rev. Cytol. 149, 145-215.