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Prof. Dr. Klaudia Brix
Prof. Dr. Klaudia Brix
Prof. Dr.
Professor of Cell Biology
Life Sciences & Chemistry

Campus Ring 1 28759 Bremen Germany

Fax: 
+49 421 200-3249
Email: 
k.brix [at] jacobs-university.de
Office: 
Research II, Room 107
Research Interests: 
  • plant-derived bioactive substances
  • proteases of the thyroid gland
  • proteases of the gastro-intestinal tract
  • proteases of the CNS with importance for memory and learning
  • proteases important for cell migration during wound healing of the skin
  • proteases important for thyroid and colon cancer

 

University Education: 
1989-1997
Habilitation and Venia legendi in Cell Biology, Univ. Bonn, Germany
1985-1987
Dissertation (Dr. rer. nat.) in Biology, Univ. Bonn, Germany
1978-1985
Diploma in Biology, Univ. Bonn, Germany

 

Fellowships and Awards: 
1996–1997
“Lise-Meitner-Habilitationsstipendiatin”, Ministry of Science and Research
of Nordrhein-Westfalen, Germany
1985–1987
Scholarship Holder “Graduiertenförderung”, Ministry of Science and
Research of Nordrhein-Westfalen, Germany

Honors: 

2016Vice Chair of Gordon Research Conference “Protein Processing, Trafficking, and Secretion”, July 24-29, 2016, Colby-Sawyer College, New London, NH, USA
2012Co-Coordinator of the SPP 1629 "THYROID TRANS ACT - Translation of Thyroid Hormone Actions beyond Classical Concepts"
2012Chair of Gordon Research Conference "Proteolytic Enzymes & Their Inhibitors", June 17-22, 2012, Il Ciocco, Lucca (Barga), Italy
2010
Vice Chair of Gordon Research Conference "Proteolytic Enzymes & Their Inhibitors", May 2-7, 2010, Il Ciocco, Lucca (Barga), Italy
2007-2009
Vice-President of International Proteolysis Society
2005-2009
Council Member of International Proteolysis Society, Representative of Europe and Africa
2005
Mentor Recognition Award, University of California San Diego, U.S.A.
since 2004
Editorial Board of European Journal of Cell Biology

 

Research and Teaching Positions: 
Career
since 01/2006
Full Professor of Cell Biology, Jacobs University Bremen (formerly: IUB), Bremen, Germany
2010-2012Vice-Speaker of the Molecular Life Science Research Center, Jacobs University Bremen
2002–2005 
Associate Professor of Cell Biology, Jacobs University Bremen, Bremen (then, IUB),
Germany
1998–2002
Assistant Professor (“Oberassistentin”) of Cell Biology; Member of the Research
Focus "Molecular Biology and Cell Biology"; Member and Research Group
Leader in the "Bonner Forum Biomedizin", therein: Manager of the Program to
support young scientists in biomedical research, Scientific Supervisor
of the Reference Center for confocal laser scanning microscopy; Group Leader
of Project B9, SFB 284, DFG (Univ. Bonn)
1998–2001
Acting Professor of Cell Biology and Vice-Chairperson (Univ. Bonn)
1989–1996
“Wissenschaftliche Assistentin” of Cell Biology and Group Leader of Project B1,
SFB 284, DFG (Univ. Bonn)
1989
Research Scientist (Univ. Düsseldorf)
1987–1988
Research Scientist in the Focus Project “Cytoskeleton”, DFG (Univ. Bonn)
 
 
Teaching Experience
since
Fall 2002
Lectures and Practical Courses in the Undergraduate Major "BCCB - Biochemistry and Cell Biology", "MCCB - Medicinal Chemistry and Chemical Biology", and "MedNat - Medical Natural Sciences"; and BCCB Program Coordinator from Fall 2006 - Spring 2014; major contributions to the Curriculum Reforms in 2008, and 2012, and 2015; University Studies Courses; Representative of the Specialization Area "Cellular and Molecular Biology" in the Graduate Program "MoLife"; Lectures, Journal Clubs, and Supervision of Laboratory Rotations and Masters Theses of Graduate Students of the Life Sciences Program "MoLife"
since
Fall 2002
Supervision of PhD-Students; Co-Supervision of PhD-Students; Host of visiting Students from Denmark, Germany, Greece, Italy, Poland, Slovenia and Switzerland; external PhD-examiner for Universities in Africa, Australia and Europe; Supervision of MSc-Students
1998–2002
Independent Lecturer, Venia legendi in “Cell Biology”, Lectures, Practical Courses, Laboratory Courses, and Seminars for Students of Biology (Univ. Bonn)
1986–2002
Independent and Dependent Supervisor of Diploma and PhD Students (Univ. Bonn)
1993–1997
Lecturer in substitution of the responsible Professor (Univ. Bonn)
1987–1997
Teaching Associate in various Practical Courses (Univ. Bonn)

 

Funded Projects: 
  • DFG grant BR 1308/13-2 “Coordination of SPP 1629 THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” – Priority Program; Führer, Brix, Biebermann. 2015 – 2018
  • DFG grant BR 1308/11-2 „Auto-regulation of the thyroid gland by classical and non-classical pathways“ in the framework of SPP 1629 THYROID TRANS ACT; PI: Klaudia Brix. 2015 – 2018
  • Symfonia, National Science Centre, Poland, ID 211744, Ref. 2013/08/W/NZ1/00696 Wplynal, “Extracellular proteolytic activity of human epithelium – role in the modulation of signal transduction”, by Prof. Dr. Jan S. Potempa (Partner 1), Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Dr. Grzegorz Dubin (Partner 2), Malopolskie Centrum Biotechnologii, Krakow, Poland; Dr. hab. Adam Jerzy Lesner (Partner 3), Faculty of Chemistry, University of Gdansk, Poland; Prof. Dr. Klaudia Brix (Partner 4), School of Engineering and Science, Jacobs University Bremen, Germany; 2015 – 2016
  • DFG grant BR 1308/13-1 “Coordination” of SPP 1629 “THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts” – Priority Program; Führer, Brix, Biebermann. 2012 – 2015
  • DFG grant BR 1308/11-1 „Auto-regulation of the thyroid gland by classical and non-classical pathways“ in the framework of SPP 1629 THYROID TRANS ACT; PI: Klaudia Brix. 2012 – 2015

 

Publications: 

Book:

  • Proteases: Structure and Function, Klaudia Brix & Walter Stöcker (Eds.), Springer-Verlag Wien 2013. http://www.springer.com/de/book/9783709108840#aboutBook, ISBN 978-3-7091-0884-0, ISBN 978-3-7091-0885-7 (eBook)., doi:10.1007/978-3-7091-0885-7. , Springer Wien, Heidelberg, New York, Dordrecht, London. Library of Congress Control Number: 2013956226.

Selection (Original Articles / Reviews):

  • Tamhane, T., R. Illukkumbura, S. Lu, G.M. Maelandsmo, M.H. Haugen, and K. Brix (2016). Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells. Biochimie 122, 208-218
  • Rezk, A., A. Al-Hashimi, W. John, H. Schepker, M.S. Ullrich, and K. Brix (2015b). Assessment of cytotoxicity exerted by leaf extracts from plants of the genus Rhododendron towards epidermal keratinocytes and intestine epithelial cells. BMC Complement Altern Med. 15:364
  • Szumska, J., M. Qatato, M. Rehders, D. Führer, H. Biebermann, D.K. Grandy, J. Köhrle, and K. Brix (2015). Trace amine-associated receptor 1 localization at the apical plasma membrane domain of Fisher rat thyroid epithelial cells is confined to cilia. Eur. Thyroid J. 4 (Suppl. 1), 30-41
  • Führer, D. / K. Brix / H. Biebermann (2015). Understanding the healthy thyroid state in 2015. Eur. Thyroid J. 4 (Suppl. 1), 1-8
  • Brix, K., J. McInnes, A. Al-Hashimi, M. Rehders, T. Tamhane, M.H. Haugen (2015). Proteolysis mediated by cysteine cathepsins and legumain - recent advances and cell biological challenges. Protoplasma 252, 755-774
  • Rezk, A., J. Nolzen, H. Schepker, D.C. Albach, K. Brix, and M.S. Ullrich (2015a). Phylogenetic spectrum and analysis of antibacterial activities of leaf extracts from plants of the genus Rhododendron. BMC Complementary & Alternative Medicine 15:67
  • Haugen, M.H., K. Boye, J.M. Nesland, S.J. Pettersen, E.V. Egeland, T. Tamhane, K. Brix, G.M. Maelandsmo, and K. Flatmark (2015).  High expression of the cysteine proteinase legumain in colorectal cancer - Implications for therapeutic targeting. Eur. J. Cancer 51, 9-17
  • Tamhane, T. / M. Arampatzidou, V. Gerganova, M. Tacke, R. Illukkumbura, S. Dauth, N. Schaschke, C. Peters, T. Reinheckel, and K. Brix (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biol. Chem. 395, 1201-1219
  • Führer, D. / K. Brix / H. Biebermann (2014). Übersicht / Review article: Schilddrüsenhormonwirkung – jenseits klassischer Konzepte. Das Schwerpunktprogramm „THYROID TRANS ACT“ (SPP1629) der Deutschen Forschungsgemeinschaft. Thyroid hormone action beyond classical concepts. The priority programme „THYROID TRANS ACT“ (SPP1629) of the German Research Foundation. Dtsch. Med. Wochenschr. 139, 492-496
  • Haugen, M.H., H.T. Johansen, S.J. Pettersen, R. Solberg, K. Brix, K. Flatmark, and G.M. Maelandsmo (2013). Nuclear legumain activity in colorectal cancer. PLoS One 8(1), e52980
  • Brix, K., D. Führer, and H. Biebermann (2011). Molecules imprtant for thyroid hormone synthesis and action - known facts and future perspectives. Thyroid Research 4 (Suppl 1), S9
  • Dauth, S., R.F. Sirbulescu, S. Jordans, M. Rehders, L. Avena, J. Oswald, A. Lerchl, P. Saftig, and K. Brix (2011). Cathepsin K deficiency in mice induces structural and metabolic changes in the cenetral nervous system that are associated with learning and memory deficits. BMC Neuroscience 12, 74. 
  • Dauth, S., M. Arampatzidou, M. Rehders, D. M. T. Yu, D. Führer, and K. Brix (2011). Thyroid cathepsin K - roles in physiology and thyroid disease. Clin. Rev. Bone Miner. Metab. 9, 94-106.
  • Jordans, S., S. Jenko-Kokalj, N. M. Kühl, S. Tedelind, W. Sendt, D. Brömme, D. Turk, and K. Brix (2009). Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochemstry 10, 23. Highly Accessed.
  • Mayer, K., A. Vreemann, H. Qu, and K. Brix (2009). Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Biol. Chem. 390, 471-480.
  • Brix, K., A. Dunkhorst, K. Mayer, and S. Jordans (2008). Cysteine cathepsins: Cellular roadmap to different functions. Biochimie 90, 194-207
  • Büth, H., P.L. Buttigieg, R. Ostafe, M. Rehders, S.R. Dannenmann, N. Schaschke, H.-J. Stark, P. Boukamp, and K. Brix (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. Eur. J. Cell Biol. 86, 747-761
  • Brix, K., and S. Jordans (2005). News & Views: Watching proteases in action. Nature Chem. Biol. 1, 186-187.
  • Brix, K. (2005). Chapter 05: Lysosomal Proteases: Revival of the Sleeping Beauty. In: Lysosomes, edited by Paul Saftig, Eurekah.com. Landes Bioscience. REVIEW.
  • Friedrichs, B., C. Tepel, Th. Reinheckel, J. Deussing, K. von Figura, V. Herzog, Ch. Peters, P. Saftig, and K. Brix (2003). Thyroid functions of mouse cathepsins B, K, and L. J. Clin. Invest. 111, 1733-1745.
  • Linke, M., V. Herzog, and K. Brix (2002). Trafficking of lysosomal cathepsin B – green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J. Cell Sci. 115, 4877-4889.
  • Brix, K., M. Linke, C. Tepel, and V. Herzog (2001). Cysteine proteinases mediate extracellular prohormone processing in the thyroid. Review. Biol. Chem. 382, 717-725.
  • Tepel, C., D. Brömme, V. Herzog, and K. Brix (2000). Cathepsin K in thyroid epithelial cells: Sequence, localization, and possible function in extracellular proteolysis of thyroglobulin. J. Cell Sci. 113, 4487-4498.
  • Brix, K., P. Lemansky, and V. Herzog (1996). Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells. Endocrinology 137, 1963-1974.
  • Brix, K., and V. Herzog (1994). Extrathyroidal release of thyroid hormones from thyroglobulin by J774 mouse macrophages. J. Clin. Invest. 93, 1388-1396.
  • Stockem, W., and K. Brix (1994). Analysis of microfilament organization and contractile activities in Physarum. Int. Rev. Cytol. 149, 145-215.

 

Other Professional Activities: 
Memberships in Scientific Societies
ASCB
American Society for Cell Biology
DGEDeutsche Gesellschaft für Endokrinology; therein: Sektion Schilddrüse
DGZ
German Society for Cell Biology
ESE
European Society for Endocrinology
ETA
European Thyroid Association
IPS
International Proteolysis Society
NYAS
New York Academy of Sciences
 
 
Reviewing Activities
Editorial Boards
European Journal of Cell Biology (since 2004)
Protoplasma, Review Editor Animal Cell Biology (since 2016)
ad hoc reviewsCouncils, Foundations, Journals, Study Groups 
 
 
Academic Committees and Responsibilities
since 2003
Scientific Head and Coordinator of the Reference Center for Confocal Laser Scanning Microscopy at Jacobs University Bremen
since 2002
Biological Safety Officer, Radiation Safety Officer, Jacobs University Bremen (formerly IUB)
2005-2012Committee Member of International Center for Transdisciplinary Studies ICTS at Jacobs University Bremen
2004-2014Member of the Graduate Admissions Committee "MoLife"
2004-2014DHV-Representative
2003–2005
Organiser of the Molecular Life Sciences Seminar, School of Engineering and Science, IUB
2002–2004,
and
2006-2008
Member of the Steering Committee, Faculty Club e.V., IUB, now University Club e.V. at Jacobs University Bremen
2002–2004
Member of the Academic Integrity Committee, International University Bremen
1999–2002
Member of the Committee for Biological Safety Regulations, Univ. Bonn
2000–2001
Member of the Advisory Board of the Representative for Equal Opportunity, Univ. Bonn
1998–2001
Committee Member of the Division of Biology, Member of the Faculty of Mathematics and Life Sciences, Vice Chairperson of the Institute of Cell Biology, Univ. Bonn
1995–1997
Representative of the Scientific Fellows of the Institute of Cell Biology, Univ. Bonn