Dr. Julia Oswald, Cambridge University (group of William Harris)
Title of the talk:
The Role of Notch Signalling in Retinal Cell Fate Specification in Zebrafish
The zebrafish retina is comprised of five neuronal cell types, including retinal ganglion cells, amacrine cells, horizontal cells, bipolar cells and photoreceptors, as well as a single type of glial cell, the Müller glia, which are born in a conserved histogenic order from equipotent, pluripotent retinal progenitor cells. Upon differentiation all retinal cell types are arranged in highly organized layers, constituting a complex neuronal network. In order to shape a complex tissue like the retina, several developmental processes including cell proliferation, differentiation and cell death need to be tightly regulated to ensure the generation of different neuronal cell types in correct amounts and at the right location. For those processes to be coordinated during development, various signalling pathways and fate determinants are required to interact. However, the nature of crosstalk between pathways such as Notch signalling and key regulators of lineage commitment and cellular differentiation is only starting to be understood.
Further info: Prof. Dr. Sebastian Springer, Professor of Biochemistry and Cell Biology, Focus Area: Health - Life Sciences & Chemistry, Email: s.springer [at] jacobs-university.de, Tel: +49 421 200-3243, Link to Homepage: http://www.jacobs-university.de/ses/sspringer