Research on Pdr5 and Multidrug Resistance
Cell resistance to drugs is a growing problem in medicine. Proteins in the cell membrane, so-called transporters, are primarily responsible for this multidrug resistance (MDR). These proteins shuttle the drugs back out of the cell before they can become effective. A joint project of Jacobs University Bremen and Heinrich-Heine-University Düsseldorf, funded by the German Research Foundation (DFG), is now investigating the properties of the transporter Pdr5, which acts as a pump. This is particularly suitable as a model system.