Welcome to the home page of the Springer Laboratory

Our life sciences research investigates the maturation, peptide loading, and intracellular trafficking of major histocompatibility complex (MHC) class I molecules and other membrane proteins using cell biological, biochemical, biophysical, and theoretical approaches.

We also develop novel methods for the introduction of hydrophilic molecules into mammalian cells, and for the detection of biomolecules in- and outside cells.

Please use the links on the left to reach the area of your interest. If you would like more information, send us an

Our MOOC (massive open online course) "DNA - From Structure to Therapy" will start in the middle of April. Check it out!  

Watch the video abstract on YouTube of our latest paper: S. Springer, P. Malkus, B. Borchert, U. Wellbrock, R.A. Lesch, R. Duden, R. Schekman: Regulated oligomerization induces uptake of a membrane protein into COPII vesicles independent of its cytosolic tail. Traffic (2014), 5 (2014), p. 531-545!

We congratulate Randy Schekman, University of California at Berkeley, on sharing the Nobel Prize in Physiology or Medicine 2013. Sebastian Springer was a postdoc with Randy between 1996 and 2001.