04/12/2016 MOLIFE RESEARCH SEMINAR: Prof. Dr. Ulrich Kortz
Tuesday, April 12, 2016 - 13:00
Lecture Hall of Research II
Prof. Dr. Ulrich Kortz, Professor of Chemistry, Jacobs Univesity Bremen
Discrete Metal-Oxides in Biology: From Inorganic Synthesis via Biomedical Studies to the Nobel Prize
Polyoxometalates (POMs) are discrete metal-oxides with a large variety of shape, size, structure, and composition, and their functionalization by incorporation of transition metal or rare earth ions has led to many novel compounds.1 Covalent attachment of organometallic moieties to POMs leads to organic-inorganic hybrid species, comprising features of both organic and inorganic components, resulting in potential applications as antiviral or antibacterial agents.
Our group has prepared numerous organometallic POMs over the years, mainly focusing on Sn, Ru, and very recently also Te.2 Recently we have developed a novel family of organo-SbIII-functionalized POMs, in which the exact number of incorporated organo-SbIII units can be deliberately tuned by careful control of the reaction parameters.3 In addition, the type of organic functionality can be modified, leading to control of steric and electronic features. All these species are solution-stable in physiological medium. The inhibitory activity of these POMs against different types of bacteria has been studied, revealing an interesting structure-activity relationship.
1. M. T. Pope, U. Kortz, Polyoxometalates, in Encyclopedia of Inorganic and Bioinorganic Chemistry, Wiley, Hoboken, 2012.
2. B. Kandasamy, B. S. Bassil, A. Haider, J. Beckmann, B. Chen, N. S. Dalal, U. Kortz, J. Organomet. Chem. 2015, 796, 33.
3. P. Yang, B. S. Bassil, Z. Lin, A. Haider, G. Alfaro-Espinoza, M. S. Ullrich, C. Silvestru, U. Kortz, Chem. Eur. J.2015, 21, 15600.