MoLife Research Seminar by;
Dr. Andreas Martin Lisewski, Jacobs University Bremen
Title of the talk:
Drugs and drug targets in the human malaria parasite Plasmodium falciparum: Artemisinin and beyond
Plasmodium falciparum is the most deadly species that causes human malaria, which worldwide leads to ~300 million clinical cases and about half a million deaths annually. Today artemisinins are the magic bullet against human malaria. But given the waning efficacy of artemisinins observed recently, and the resulting future danger of global artemisinin resistance, there is an urgent need to find new drugs that one day could replace artemisinins. Using a network based computational approach that we have pioneered we elucidate still unknown mechanisms of action and resistance mechanisms of key antimalarial drugs, such as artemisinin and chloroquine, and systemically explore new candidates in computational and in high-throughput studies.
Dr. Andreas Martin Lisewski Email: a.lisewski [at] jacobs-university.de Department of Life Sciences & Chemistry Research II/ Room 75 Jacobs University Bremen